abstract：:K. Suzuki, S. Kostin, V. Person, A. Elsässer and J. Schaper. Time Course of the Apoptotic Cascade and Effects of Caspase Inhibitors in Adult Rat Ventricular Cardiomyocytes. Journal of Molecular and Cellular Cardiology (2001) 33, 983-994. Interpretation of the rate of apoptosis in diseased hearts is hampered by the fac...

journal_title：Journal of molecular and cellular cardiology

authors： Suzuki K,Kostin S,Person V,Elsässer A,Schaper J

更新日期：2001-05-01 00:00:00

abstract：:Hypertrophic cardiomyopathy (HCM), a relatively common disease, is diagnosed clinically by unexplained cardiac hypertrophy and pathologically by myocyte hypertrophy, disarray, and interstitial fibrosis. HCM is the most common cause of sudden cardiac death (SCD) in the young and a major cause of morbidity and mortality...

journal_title：Journal of molecular and cellular cardiology

authors： Marian AJ,Roberts R

更新日期：2001-04-01 00:00:00

abstract：:We examined the relative roles of the mitogen-activated protein kinases (MAPK) in mediating the alpha1-adrenergic receptor (alpha1-AR) stimulated hypertrophic phenotype in adult rat ventricular myocytes (ARVM). Norepinephrine (NE; 1 microM) in the presence of the beta -AR antagonist propranolol (Pro; 2 microM) caused ...

journal_title：Journal of molecular and cellular cardiology

authors： Xiao L,Pimental DR,Amin JK,Singh K,Sawyer DB,Colucci WS

更新日期：2001-04-01 00:00:00

abstract：:Antibodies directed against the second extracellular loop of G protein-coupled receptors have been shown to exert "agonist-like" activities. In order to test the hypothesis that this is a general phenomenon, antibodies were raised in rabbits against a synthetic peptide corresponding to the second extracellular loop of...

journal_title：Journal of molecular and cellular cardiology

authors： Sallé L,Eftekhari P,Aupart M,Cosnay P,Hoebeke J,Argibay JA

更新日期：2001-03-01 00:00:00

abstract：:beta(1)integrin-deficient (beta(1)-/-) ES cells showed increased differentiation of cardiac cells characterized by reduced adhesion and high beating frequency. Whereas in whole embryoid body outgrowths of beta(1)-/- cells maximum levels of alpha(v), beta(3)and beta(5)integrin mRNA were delayed and transiently upregula...

journal_title：Journal of molecular and cellular cardiology

authors： Guan K,Czyz J,Fürst DO,Wobus AM

更新日期：2001-03-01 00:00:00

abstract：:Cardiac-specific expression of an activated calcineurin protein in the hearts of transgenic (CLN) mice produces a profound hypertrophy that rapidly progresses to heart failure. While calcineurin is regulated by Ca2+, the potential effects of calcineurin on cardiac myocyte Ca2+ handling has not been evaluated. To this ...

journal_title：Journal of molecular and cellular cardiology

authors： Yatani A,Honda R,Tymitz KM,Lalli MJ,Molkentin JD

更新日期：2001-02-01 00:00:00

abstract：:Since the recognition of the importance of calcium ions to cardiac contractility, the effects of alterations in calcium homeostasis on cardiac myocyte function have attracted immense attention. However, the possibility that changes in extracellular calcium concentration or the administration of calcium channel blocker...

journal_title：Journal of molecular and cellular cardiology

authors： Shivakumar K,Kumaran C

更新日期：2001-02-01 00:00:00

abstract：:Gain- and loss-of-function strategies using transgenic over-expression and targeted ablation of candidate genes in in the mouse have provided important mechanistic insights into cardiovascular development, physiology and disease. An essential, but challenging step is the functional analysis of the resultant phenotype....

journal_title：Journal of molecular and cellular cardiology

authors： Hoit BD

更新日期：2001-01-01 00:00:00

abstract：:Hypertrophic cardiomyopathy occurs in two variants, either as an autosomal dominant familial disorder or as a sporadic disease without familial involvement. Different genes coding sarcomeric proteins of the heart have been identified as causing hypertrophic cardiomyopathy. Missense mutations in the cardiac beta-myosin...

journal_title：Journal of molecular and cellular cardiology

authors： Greber-Platzer S,Marx M,Fleischmann C,Suppan C,Dobner M,Wimmer M

更新日期：2001-01-01 00:00:00

abstract：:The damage of myocardial infarction (MI) is often progressive. A possible mechanism for subsequent myocardial damage and heart failure after MI is immune response against cardiac self-antigens. The purpose of our study was to test the hypothesis that cytotoxic T lymphocytes are activated following acute MI and may hav...

journal_title：Journal of molecular and cellular cardiology

authors： Varda-Bloom N,Leor J,Ohad DG,Hasin Y,Amar M,Fixler R,Battler A,Eldar M,Hasin D

更新日期：2000-12-01 00:00:00

abstract：:We made novel measurements of the influence of rest intervals and stimulation frequency on twitch contractions and on sarcoplasmic reticulum (SR) Ca(2+)-content (using rapid cooling contractures, RCCs) in isolated ventricular muscle strips from rat and rabbit hearts at a physiological temperature of 37 degrees C. In a...

journal_title：Journal of molecular and cellular cardiology

authors： Maier LS,Bers DM,Pieske B

更新日期：2000-12-01 00:00:00

abstract：:In mammalian species, including man, the duration of myocardial contraction is shorter in atria than ventricles. Total contraction time depends at least in part on phosphorylation and dephosphorylation of cardiac regulatory proteins. Dephosphorylation reactions are mediated by protein phosphatases. In the mammalian he...

journal_title：Journal of molecular and cellular cardiology

authors： Lüss H,Klein-Wiele O,Bokník P,Herzig S,Knapp J,Linck B,Müller FU,Scheld HH,Schmid C,Schmitz W,Neumann J

更新日期：2000-12-01 00:00:00

abstract：:Heart failure of diverse causes is associated with abnormalities of sarcoplasmic reticulum (SR) Ca(2+)transport. The purpose of this study was to determine whether the thyroid hormone analogue, 3,5-diiodothyropropionic acid (DITPA), prevents abnormal Ca(2+)transport and expression of SR proteins associated with post-i...

journal_title：Journal of molecular and cellular cardiology

authors： Pennock GD,Spooner PH,Summers CE,Litwin SE

更新日期：2000-11-01 00:00:00

abstract：:Increased heart rate enhances cardiac contractility and accelerates relaxation. Both the force- and relaxation-frequency relationships are critical to myocardial function, especially during stress, and have been shown to be impaired in senescent myocardium. While senescent myocardium is characterized by decreased sarc...

journal_title：Journal of molecular and cellular cardiology

authors： Lim CC,Apstein CS,Colucci WS,Liao R

更新日期：2000-11-01 00:00:00

abstract：:Intracellular Na(+)accumulation and K(+)loss play important roles in the pathogenesis of arrhythmias and injury in the ischemic heart. We investigated the role of metabolically sensitive connexin hemichannels as a potential route for Na(+)influx and K(+)efflux during ischemia, using dye uptake and electrophysiological...

journal_title：Journal of molecular and cellular cardiology

authors： Kondo RP,Wang SY,John SA,Weiss JN,Goldhaber JI

更新日期：2000-10-01 00:00:00

abstract：:Ischemic preconditioning reduces infarct size and improves cardiac function in various species, including mice. The mechanism for ischemic preconditioning protection is not entirely clear and activation of alpha(1B)-adrenergic receptors (AR) is believed to be involved. Transgenic mice expressing constitutively active ...

journal_title：Journal of molecular and cellular cardiology

authors： Gao XM,Wang BH,Woodcock E,Du XJ

更新日期：2000-09-01 00:00:00

abstract：:Understanding the process of Ca(2+)/Mg(2+)exchange during muscle excitation and relaxation is fundamental to elucidating the mechanism of Ca(2+)-regulated muscle contraction. During the resting phase, the C-domain of cardiac troponin C may be occupied by either Ca(2+)or Mg(2+). Here, complexes of recombinant cardiac t...

journal_title：Journal of molecular and cellular cardiology

authors： Finley N,Dvoretsky A,Rosevear PR

更新日期：2000-08-01 00:00:00

abstract：:Previous studies from our laboratory and others indicate that contraction-induced mechanical loading of cultured neonatal rat ventricular myocytes produces many of the phenotypic changes associated with cardiomyocyte hypertrophy in vivo, and that these changes occur via the activation of serine-threonine protein kinas...

journal_title：Journal of molecular and cellular cardiology

authors： Strait JB,Samarel AM

更新日期：2000-08-01 00:00:00

abstract：:Nitric oxide (NO) has been reported to play an important role in the late phase of ischemic preconditioning (PC) in the rabbit heart. However, the role of NO in the early phase of ischemic PC ("classical PC") is controversial. Accordingly, the present study was designed to determine whether NO contributes to the cardi...

journal_title：Journal of molecular and cellular cardiology

authors： Nakano A,Liu GS,Heusch G,Downey JM,Cohen MV

更新日期：2000-07-01 00:00:00

abstract：:Previous work suggests that strontium ions (Sr(2+)) are less effective than calcium ions (Ca(2+)) at supporting excitation-contraction (EC) coupling in cardiac muscle. We therefore tested whether this was due to differences in the uptake and release of Ca(2+)and Sr(2+)by the sarcoplasmic reticulum (SR) of rat ventricu...

journal_title：Journal of molecular and cellular cardiology

authors： Spencer CI,Barsotti RJ,Berlin JR

更新日期：2000-07-01 00:00:00

abstract：:We have investigated whether translocation of constitutive low molecular weight stress proteins (alphaB-crystallin and HSP27) to the myofilament/cytoskeletal compartment occurs during ischemic preconditioning and assessed if this is causally associated with cardioprotection. Triton-insoluble preparations from fresh or...

journal_title：Journal of molecular and cellular cardiology

authors： Eaton P,Awad WI,Miller JI,Hearse DJ,Shattock MJ

更新日期：2000-06-01 00:00:00

abstract：:Perlecan, a basal lamina proteoglycan, has been shown to interact with other extracellular matrix (ECM) components, especially type IV collagen, and is thus involved in ECM formation. Perlecan has also been postulated to promote growth factor-receptor interactions, including the binding of basic fibroblast growth fact...

journal_title：Journal of molecular and cellular cardiology

authors： Nakahama M,Murakami T,Kusachi S,Naito I,Takeda K,Ohnishi H,Komatsubara I,Oka T,Ninomiya Y,Tsuji T

更新日期：2000-06-01 00:00:00

abstract：:The purpose of the present study was to determine whether age-related changes in the expression and function of the cardiac isoform of the sarcoplasmic reticulum Ca(2+)-ATPase (SERCA2a) play a role in SR Ca(2+)release and cell contraction. SERCA2a protein levels and subcellular localization were compared between fetal...

journal_title：Journal of molecular and cellular cardiology

authors： Chen F,Ding S,Lee BS,Wetzel GT

更新日期：2000-05-01 00:00:00

abstract：:Ventricular hypertrophy is associated with an increase in action potential (AP) duration which is potentially arrhythmogenic. The implication of the Na-Ca exchange current (I(Na-Ca)) in the lengthening of the AP is controversial. The role of this current in the increased duration of the low plateau of the AP in hypert...

journal_title：Journal of molecular and cellular cardiology

authors： Espinosa L,Chouabe C,Morales A,Lachuer J,Georges B,Fatemi M,Terrenoire C,Tourneur Y,Bonvallet R

更新日期：2000-04-01 00:00:00

abstract：:To understand better the pathophysiological roles of the vagal efferent system in ischemic heart diseases, we examined endogenous acetylcholine (ACh) release in the myocardium in vivo. Acute myocardial ischemia was induced in anesthetized cats by a 60-min occlusion of the left anterior descending coronary artery (LAD)...

journal_title：Journal of molecular and cellular cardiology

authors： Kawada T,Yamazaki T,Akiyama T,Sato T,Shishido T,Inagaki M,Takaki H,Sugimachi M,Sunagawa K

更新日期：2000-03-01 00:00:00

abstract：:The cardiac troponin I gene has been described to be associated with hypertrophic cardiomyopathy. Until now, mutations in this gene have been found only in the Japanese population. We now present the first non-Japanese family, from northern Sweden, with a mutation in the cardiac troponin I gene. Clinical diagnose was ...

journal_title：Journal of molecular and cellular cardiology

authors： Mörner S,Richard P,Kazzam E,Hainque B,Schwartz K,Waldenström A

更新日期：2000-03-01 00:00:00

abstract：:Iron overload is associated with long-term cardiac iron accumulation and tissue changes such as fibrosis. To determine short-term iron-dependent changes in expression of genes associated with iron homeostasis and fibrosis we measured mRNA on Northern blots prepared from cultured rat neonatal cardiomyocytes and non-myo...

journal_title：Journal of molecular and cellular cardiology

authors： Parkes JG,Liu Y,Sirna JB,Templeton DM

更新日期：2000-02-01 00:00:00

abstract：:Oxygen deprivation for prolonged periods leads to cardiac cell death and ventricular dysfunction. The ability to prevent myocardial cell death would be of significant therapeutic value in maintaining cardiac function after injury. While caspases have been suggested to play a critical role in apoptosis, their involveme...

journal_title：Journal of molecular and cellular cardiology

authors： de Moissac D,Gurevich RM,Zheng H,Singal PK,Kirshenbaum LA

更新日期：2000-01-01 00:00:00

abstract：:Cardiocyte loss during myocardial hypertrophy leads to progressive dysfunction in human hearts with chronic hemodynamic overload. The mechanism for such cell elimination is unknown. We examined lysosomal participation in cardiocytic degradation present in human cardiac biopsies, utilizing electron microscopic cytochem...

journal_title：Journal of molecular and cellular cardiology

authors： Yamamoto S,Sawada K,Shimomura H,Kawamura K,James TN

更新日期：2000-01-01 00:00:00

abstract：:The length-dependence of myofilament Ca(2+) sensitivity is considered to be an important component of the steep force-length relationship in cardiac muscle (Frank-Starling relation). Recent studies suggest that Ca(2+) sensitivity is a function of the number of strong-binding cross-bridge interactions formed at a given...

journal_title：Journal of molecular and cellular cardiology

authors： Smith SH,Fuchs F

更新日期：1999-12-01 00:00:00

abstract：:Human immunodeficiency virus (HIV, lentivirus) type-1 based vectors have a number of attractive features for gene therapy, including the ability to transduce non-dividing cells and long term transgene expression. We used a three-plasmid expression system to generate pseudotyped lentivirus-based vectors by transient tr...

journal_title：Journal of molecular and cellular cardiology

authors： Sakoda T,Kasahara N,Hamamori Y,Kedes L

更新日期：1999-11-01 00:00:00

abstract：:The aim was to determine whether adaptation to chronic hypoxia protects the heart against ischemic arrhythmias and whether ATP-dependent potassium channels (K(ATP)) play a role in the antiarrhythmic mechanism. Adult male rats were adapted to intermittent high altitude hypoxia (5000 m, 4 h/day) and susceptibility to is...

journal_title：Journal of molecular and cellular cardiology

authors： Asemu G,Papousek F,Ostádal B,Kolár F

更新日期：1999-10-01 00:00:00

abstract：:The role of protein kinase C (PKC) in the protection of ischemic preconditioning (PC) is still controversial, partly because of the multiple isozymes of PKC and the inability to directly measure PKC activity in vivo. In this study we have used novel peptide inhibitors which correspond to part of the amino acid sequenc...

journal_title：Journal of molecular and cellular cardiology

authors： Liu GS,Cohen MV,Mochly-Rosen D,Downey JM

更新日期：1999-10-01 00:00:00

abstract：:Although captopril, an angiotensin-converting enzyme (ACE) inhibitor, has been shown to exert a beneficial effect on cardiac function in heart failure, its effect on the status of sarcoplasmic reticulum (SR) Ca(2+) transport in the failing heart has not been examined previously. In order to determine whether captopril...

journal_title：Journal of molecular and cellular cardiology

authors： Shao Q,Ren B,Zarain-Herzberg A,Ganguly PK,Dhalla NS

更新日期：1999-09-01 00:00:00

abstract：:Functional studies of different human cell types have been successfully conducted under in vitro conditions. Despite many efforts, it has not been possible to develop a human myocardial preparation in which contractile function can be studied over several days. We hypothesize that by mimicking the in vivo situation in...

journal_title：Journal of molecular and cellular cardiology

authors： Janssen PM,Lehnart SE,Prestle J,Hasenfuss G

更新日期：1999-08-01 00:00:00

abstract：:The importance of endogenous and exogenous estrogen levels to the development of cardiovascular disease in women in controversial. The purpose of our study was to examine the effect of estrogen on the development of hypertension, cardiac hypertrophy, ventricular function, and gene expression for atrial natriuretic pep...

journal_title：Journal of molecular and cellular cardiology

authors： Sharkey LC,Holycross BJ,Park S,Shiry LJ,Hoepf TM,McCune SA,Radin MJ

更新日期：1999-08-01 00:00:00

abstract：:Activation of the antiogensin II, type 1 (AT1) receptor mediates the myocardial response to numerous hypertrophic stimuli. This study tested the hypothesis that 2-tetradecylglycidic acid (TDGA), an oxirane carboxylate inhibitor of mitochondrial carnitine plamitoyltransferase-1, induces myocardial hypertrophy via the A...

journal_title：Journal of molecular and cellular cardiology

authors： Wolkowicz PE,Urthaler F,Forrest C,Shen H,Durand J,Wei CC,Oparil S,Dell'Italia LJ

更新日期：1999-08-01 00:00:00

abstract：:Transgenic mice with cardiac-specific overexpression of G alpha q exhibit a biochemical and physiological phenotype of load-independent cardiac hypertrophy with contractile dysfunction. To elucidate the cellular basis for altered contractility, we measured cellular contraction, Ca(2+)transients, and l -type Ca(2+)chan...

journal_title：Journal of molecular and cellular cardiology

authors： Yatani A,Frank K,Sako H,Kranias EG,Dorn GW 2nd

更新日期：1999-07-01 00:00:00

abstract：:Beta-adrenergic receptor kinase 1 (beta ARK1) participates in the desensitization of beta-adrenergic receptors by uncoupling the signal transduction. The present study was designed to examine whether neurohumoral increase is crucial for the activation of beta ARK1 in heart failure. Four weeks after the ligation of rat...

journal_title：Journal of molecular and cellular cardiology

authors： Ishigai Y,Mori T,Moriyama S,Shibano T

更新日期：1999-06-01 00:00:00

abstract：:Fibrosis, a consequence of tissue repair, can become a final common pathway to organ failure, if progressive. Prevention and regression of organ fibrosis represent targets of considerable interest. The natural fate of fibrosis differs among various tissues being either persistent, progressive or regressive. Cellular a...

journal_title：Journal of molecular and cellular cardiology

authors： Zhang J,Sun Y,Zhang JQ,Ramires FJ,Weber KT

更新日期：1999-05-01 00:00:00